A large number of HIF-1α enter the nucleus, bind to HIF-1β, activate downstream hypoxia-response elements, then up-regulate the expressions of vascular endothelial growth factor (VEGF), angiogenin and epidermal growth factor at the protein level, and finally promote tumor cell proliferation, migration, invasion and angiogenesis 11, 12. This evidence concerns the gene HIF1A and neoplasm.