In summary, we are delighted that our present study provides strong and consistent two-fold evidence for the first timeꓽfirstly that VES-induced anti-tumour activity on human cervical cancer cells is mediated, at least in part, by the CD47-SIRPα pathway in vivo and in vitro, and secondly that the phagocytosis of tumour cells by macrophages is implicated in this process. Here, SIRPA is linked to neoplasm.