To test if the formation of APVTs in PCNSLs could be regulated by a brain special ER microenvironment, we observed the interaction between HBMECs and different GCB-DLBCL (Ly1 and Ly8) or ABC-DLBCL (Ly10 and HBL1) cell lines in normoxic and hypoxic condition. Here, LINC00458 is linked to diffuse large B-cell lymphoma.