Our experimental results show that the expression of GTPBP2 in NSCLC cancer tissues is higher than that of normal lung tissues, and its high expression is closed related to the TNM stage of lung cancer patients, lymph node metastasis and the poor prognosis of patients, indicating that GTPBP2 plays a role in the occurrence and development of NSCLC important role. This evidence concerns the gene GTPBP2 and lung cancer.