Using the TCGA databases to analyze the expression and survival of YTHDF2 or IRS1 in uterine corpus endometrial carcinoma (UCEC), we found that the YTHDF2 was significantly upregulated and IRS1 was significantly downregulated in primary tumor compared to normal tissue, this is consistent with our findings, but the effect of YTHDF2 or IRS1 expression level on UCEC patient survival is not significantly (data not shown), this results beyond our expected results, and the association between YTHDF2 and the survival of UCEC need to be explored in the future. This evidence concerns the gene IRS1 and neoplasm.