PTGS2 and Hyperglycemia: In a different study, Ha et al. [117] revealed that hyperglycemia in glial cells induced NF-κB activation, which further resulted in increased concentration of various cell adhesion genes and inflammatory genes (TNF-α, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase, IL-1β, and interleukin 6 (IL-6)).