MYO15A and deafness: We concluded the c.5681T>C variant to be pathogenic for several reasons: (a) the amino acid residues at the mutation sites were highly conserved; (b) several pathogenic mutations have been found near this location; (c) detected in 2 sporadic pedigrees with similar DFNB3 phenotype; (d) the MYO15A gene is highly heterogeneous, and c.6340G>A mutation is a known disease mutation, which combined with c.5681T>C causing deafness.