In a recent transcriptomics study performed on whole blood of OI patients with COL1A1 mutations (Zhytnik et al., 2020), the authors observed a decreased expression of DKK3 from the same Dickkopf family of Wnt signaling antagonisers in COL1A1-OI patients compared to healthy controls. Here, COL1A1 is linked to osteogenesis imperfecta.