However, other studies have shown that variants of certain genes, including FTO alpha-ketoglutarate dependent dioxygenase, retinoic acid induced 1, MAGE family member L2, and melanocortin 4 receptor contribute to obesity development (Fall and Ingelsson, 2014; Poitou et al., 2020). Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.