PDLIM5 encodes several splice variants, whose expression is tissue specific and temporally regulated (Zheng et al., 2010). Alternative splicing plays an important role in heart development and in the development of cardiopathies (Weeland et al., 2015). Polymorphisms in PDLIM3 (rs4861669, rs4862543) and PDLIM5 (rs1056772) were significantly associated with idiopathic dilated cardiomyopathy (IDCM) in Chinese Han patients (Wang et al., 2019). This evidence concerns the gene PDLIM3 and idiopathic dilated cardiomyopathy.