It was also discovered that the VEGF (Tong et al., 2006), cAMP (Knerr et al., 2005), oxidative phosphorylation, B/T cell receptor, natural killer cell-mediated cytotoxicity (Vaupel and Multhoff, 2018), and cardiac muscle contraction (Amoasii et al., 2018) signaling pathways were enriched, which are related to hypoxic adaptation systems and are important for oxygen transportation, environmental sensing, energy metabolism, and infection and immune defense systems. Here, VEGFA is linked to infection.