In the present study, by using a unilateral ureteric obstruction (UUO)-induced mouse model of renal fibrosis, and culturing renal TECs exposed to TGFB1, we demonstrated that PARK7 protects against renal TIF and related kidney injury by inducing SOD2 and scavenging ROS. This evidence concerns the gene TGFB1 and Ureteral obstruction.