In addition, the hypoxia score in both datasets showed negative correlations with ten genes in the tumor inflammation signature reflecting antigen presenting cell abundance (HLA-DRB1 and CMKLR1), T-cell/NK-cell abundance (NKG7, CD8A), IFN activity (CCL5, CXCL9, CD27, CXCR6) and T-cell expressed exhaustion markers (TIGIT, LAG3). This evidence concerns the gene TIGIT and neoplasm.