PGP and Zika virus infectious disease: We found a consistent decrease in labyrinthine P-gp expression in all ZIKV-exposed groups, demonstrating that ZIKV infection during pregnancy has the potential to increase fetal exposure to P-gp substrates, such as synthetic glucocorticoids, antibiotics, antiretrovirals, antifungals, stomach-protective drugs, and nonsteroidal anti-inflammatory drugs (26).