However, bladder cancer, invasive breast carcinoma, cervical squamous cell carcinoma, endocervical adenocarcinoma, colorectal cancer, diffuse large B cell lymphoma, kidney chromophobe, lung adenocarcinoma, lung squamous cell carcinoma, prostate cancer, melanoma, endometrial carcinoma, and uterine carcinosarcoma have a lower level of VISTA expression (52). This evidence concerns the gene VSIR and Familial prostate cancer.