LAG3 and Autoimmunity: Although inhibitory ICs, e.g., CTLA-4, PD-1, T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3), and VISTA, can maintain the body’s homeostasis and prevent autoimmunity, tumoral cells can also express these inhibitory ICs and shield themselves from anti-tumoral immune responses (38, 39).