10 patients presented with immunodeficiency, including hypo-IgG (6/10, 60%), hypo-IgM (10/10, 100%), hypo-IgA (8/10, 80%), low B cells count (8/10, 80%), and low NK cells count (1/10, 10%) (5, 6, 8–10). The gene discussed is CD40LG; the disease is immunodeficiency disease.