NLRP3 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: On the other side, in a recent study, IP3-mediated Ca2+ release from the endoplasmic reticulum was testified to enhance NLRP3 inflammasome activation in peripheral blood mononuclear cells (PBMCs) from APLAID patients, suggesting that NLRP3 inflammasome activation may play a role in the pathogenesis of APLAID (14).