Autoinflammatory phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) is a rare autoinflammatory disease caused by gain-of-function mutations in the PLCG2 gene. This evidence concerns the gene PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation.