The use of TNF antagonists has been associated with an increased incidence of opportunistic infections, including Staphylococcus aureus infections, listeriosis, Legionella pneumophila infections, nocardiosis and non-tuberculous mycobacterial infections, cryptococcosis, histoplasmosis, coccidioidomycosis, pneumocystosis, histoplasmosis, candidiasis, and aspergillosis, but also with reactivation of chronic HBV and latent tuberculosis infections (9). This evidence concerns the gene TNF and candidiasis.