PTX3 and infection: Ptx3-/- mice showed a higher mortality rate compared to wild-type mice in both models of infection, with 100% Ptx3-/- mice dead compared to 17% wild-type mice 72 h post intranasal infection (P = 0.005), and 100% Ptx3-/- mice dead compared to 42% wild-type mice 60 h post intraperitoneal infection (P = 0.004) (Figures 2F, G).