PTX3 and infection: To investigate the relevance of PTX3 in this model, we first measured the local and systemic levels of PTX3 during the infection and we observed robust induction of PTX3 starting from 24 hours post-infection and reaching a peak at 48h post-infection, following systemic dissemination, as indicated by spleen bacterial load (Figures 1A, B and Supplementary Figure S2A, B).