Although we did not determine whether this suppressive effect was direct or indirect on autoreactive B cells through CD4+ or CD8+ T cells or by synergistic effect by those cells with tolerized B cells and granulocytes, this data clearly suggests that pCons-induced regulatory B cells and granulocytes suppress the anti-DNA Ab production and thus play a significant role in autoimmunity. This evidence concerns the gene CD4 and Autoimmunity.