SET and neoplasm: Increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG)2 and SET nuclear proto-oncogene (SET), cytochrome C release, and activation of caspase-3, -7, and -9 were observed in NKEV-treated tumor cells; the altered expression of ER-associated markers such as protein kinase R-like ER kinase (PERK) and phosphorylated eukaryotic initiation factor (eIF)2α suggested that ER stress was involved in these processes (21).