Especially, treatment with TLR4 inhibitor TAK-242 and NF-κB inhibitor BAY 11-7082 also inhibited S100A9 protein levels in Fn-challenged Mφ and CRC cells (Figure 5D) as well as its levels in cell supernatant (Figures 5E–G). The gene discussed is TLR4; the disease is colorectal carcinoma.