DKK1 and hepatocellular carcinoma: Along with the high DKK1 level, the β-catenin accumulation was found to be elevated in tumor tissues by immunohistochemistry (IHC) staining and this was linked to poor clinical outcome, which could be observed in chondrosarcoma, triple-negative breast cancer, hepatocellular carcinoma, and human hilar cholangiocarcinoma (43–46).