Our findings are inconsistent with those from previous reports showing that NLRP3 inflammasome assembly is suppressed in IL-10−/− DCs via inhibition of the P2X purinoceptor 7 receptor (P2X7R) and reduction in the levels of intracellular Ca2+, leading to inhibition of DCs apoptosis post infection with C. muridarum (32). This evidence concerns the gene NLRP3 and infection.