Other biomarker combinations, such as ST2+REG3α+TNFR1 (96), ST2+TNFR1, T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) +TNFR1+IL6 (94), ST2+TIM3 (101), have been investigated in the plasma of HSC patients and improve detection and severity of GVHD. This evidence concerns the gene TNFRSF1A and graft versus host disease.