Discovered as GVHD biomarker by proteomic analysis, ST2 has been correlated with other promising GVHD biomarkers, such as the antimicrobial peptide regenerating islet-derived protein 3 alpha (REG3α), and soluble tumor necrosis factor receptor 1 (TNFR1). This evidence concerns the gene TNFRSF1A and graft versus host disease.