Thus, concentration of soluble ICAM-1 and E-selectin is elevated in both GVHD and SOS patients (65); soluble vascular CAM protein 1 (sVCAM-1) increased especially in patients who later develop GVHD and TA-TMA, while P-selectin levels was selectively higher in patients developing severe SOS (64, 68). This evidence concerns the gene SELE and spondylo-ocular syndrome.