TNF and chlamydia trachomatis infectious disease: Third, deficiency of TNF-αR, the specific receptor of TNF-α that is essential for mediating its biological function; injection of TNF-α antibody; or knockout of the TNF-α gene significantly reduces the severity of mouse fallopian tube lesions due to chlamydial infection, illustrating that TNF-α play an important role in immune injury induced by Chlamydia (24, 25).