Although the effect of platelets on inflammatory responses in TB depends upon the stage, site, and severity of TB infection, they appear to predominantly steer monocyte differentiation towards an anti-inflammatory phenotype: the presence of M.tb does not affect cytokine secretion from platelets themselves, but has been shown to raise IL-10 and reduce TNFα secretion by platelet-transformed macrophages (61). Here, TNF is linked to tuberculosis.