Indeed, addition of HMGB1 enhances the expression of GATA3 by TH2 cells and increases the levels of IL-4 and IL-13 (182) and uric acid is implicated in the release of IL-33 and TSLP by airway epithelial cells and the production of IL-13 after respiratory syncytial virus infection (183). Here, IL13 is linked to respiratory syncytial virus infectious disease.