DHX58 and infection: Further studies tried to reconcile the controversial regulatory roles of LGP2 by proposing that LGP2 is a concentration dependent biphasic switch: at low concentration when cells are in steady state, LGP2 enhances MDA5 activation to help fight infection, whereas at high concentration in late infection stages, LGP2 exerts a general inhibition to RIG-I and MDA5 signaling to resolve the inflammation (17, 18).