Regarding the process by which viral infection induces lipophagy, there are currently only sporadic clues, apart from the Rabs, the cross-talk between lipases and the core lipophagy machinery, mentioned in this review that induce and regulate the occurrence of lipophagy, many other factors are involved such as the transcription factor EB (TFEB) and Forkhead box protein O1 (FoxO1), calcium signaling transduction, small molecules including ethanol, etc. How these cues relate to each other, and what are the triggering molecular mechanisms specific to lipophagy are unclear. This evidence concerns the gene FOXO1 and viral infectious disease.