As such, this combination pioneered unimolecular PGDP-based research, with the cholesterol-conjugated OXM analogue DualAG and the glucagon, GLP-1 chimeric peptide “Aib2 C24 chimera 2 lactam 40K” both showing preclinical promise in murine, DIO models of obesity-diabetes [(252, 311); Table 4]. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.