In the two G2 pNETs and in the lung carcinoid, hypercalcemia was likely associated with high PTHrP; in the G1 pNET hypercalcemia was associated with elevated 1,25-dihydroxyvitamin D, a rare cause of paraneoplastic hypercalcemia in NENs. The gene discussed is PTHLH; the disease is Hypercalcemia.