Similarly, miR-193b was downregulated in GDM patients, while an in vitro study found that its aberrantly low expression in high glucose (HG)-induced trophoblasts led to cell apoptotic events by upregulating insulin-like growth factor binding protein (IGFBP5)-induced autophagy, which might result in GDM (92). This evidence concerns the gene IGFBP5 and gestational diabetes.