AFF1 and gestational diabetes: Similarly, lncRNA MEG3 was overexpressed in human umbilical vein endothelial cells (HUVECs) from GDM patients compared with healthy controls, which might have led to the downregulation of miR-370-3p and upregulation of AFF1, mainly through inhibiting the phosphatidylinositide 3-kinase (PI3K)/AKT pathway at a molecular level and thus influencing the process of GDM (50).