IRS4 and thyroid gland disorder: Across all 2925 phenotypes studied in the FinnGen project, the strongest associations discovered were with thyroid disorders (p = 1.3x10-7) and hypothyroidism (p = 8.3x10-7), which were associated to a rare Finnish-enriched haplotype (tagged by SNP rs1452561670 20 kb downstream of IRS4) (Supplemental Figure 2).