Mice also spent more time in the open in the EMZ, suggesting reduced anxiety, which is in line with previous reports that α2 and α3 subunits mediate the anxiolytic effects of unselective GABA receptor agonists (58, 59), but is not consistent with normalization of Fmr1 KO mouse behavior in this assay thus potentially limiting the face validity of this behavior test. Here, FMR1 is linked to Anxiety.