Based on the data from in vitro experiments, one would expect a protective effect following administration of the lactate receptor agonists, as the extracellular activation of neuronal HCAR1 would slow down neuronal activity (Bozzo et al., 2013; Herrera-Lopez and Galvan, 2018; de Castro Abrantes et al., 2019), exacerbated after the ischemia. Here, HCAR1 is linked to ischemia.