The NPR-C–/– mice displayed a rapid transition into HFrEF, as demonstrated by ventricular dilatation and reductions in EF and FS, whereas systolic function was not yet impaired in wild-type mice (no strain analysis by speckle tracking echocardiography was performed) (Mackasey et al., 2018). The gene discussed is NPR3; the disease is Ventriculomegaly.