AGT and atrial fibrillation: Consistent with prior studies (Wakisaka et al., 2007; Swaminathan et al., 2011; Fukui et al., 2013), we demonstrated that chronic Ang II may cause atrial enlargement, electrical and structural remodeling (fibrosis) of the atrial myocardium, and increased susceptibility to AF (Mackasey et al., 2018).