The development of diastolic dysfunction appeared independent of age, gender, body weight, and systemic hypertension in subjects homozygous for the altered NPR3 genotype with an odds ratio of 1.9, which is similar to that of systemic hypertension, a major modifiable traditional cardiovascular risk factor for diastolic dysfunction (Pereira et al., 2014). Here, NPR3 is linked to Hypertension.