Impaired activation of NPR-C signaling has been described in several pathological processes including obesity, inflammation, insulin resistance, fibrosis, ischemia, oxidative stress, remodeling, and arterial and pulmonary hypertension (Hobbs et al., 2004; Egom et al., 2017a,c, 2019; Sarzani et al., 2017; Egom, 2019). The gene discussed is NPR3; the disease is obesity due to melanocortin 4 receptor deficiency.