Moreno-Santos et al. (2019) investigated the relationship between the expression and signaling of EAT NPR-C and the progression of CAD in humans in a cohort of individuals with angiographically normal coronary arteries, stable CAD, and acute coronary syndrome (ACS). The authors showed that patients with ACS have lower expression of EAT NPR-C at both the protein and mRNA levels compared to patients with stable CAD or angiographically normal coronary arteries (Finck and Kelly, 2006; Díez, 2017; Moreno-Santos et al., 2019). This evidence concerns the gene NPR3 and coronary artery disorder.