NPR3 and metabolic syndrome: To support this hypothesis, several experimental studies have demonstrated a strong relationship between increased adiposity, NPR-C signaling, arterial hypertension, dyslipidemia, and inflammation and insulin resistance; which, in the long term, may result in impairment of endothelial, diastolic, systolic, arterial, and skeletal muscle functions (Paulus and Tschöpe, 2013; Shah et al., 2016; Obokata et al., 2017; Clerico et al., 2018).