Studies performed in RA animal models showed that TGP significantly reduced the swelling of the arthritic foot and paw in rats with AA and CIA, modulated abnormal immune function in AA and CIA rats, reduced serum anti–type II collagen antibodies in CIA, and inhibited the secretion of IL-1, TNF-α, and other inflammatory cytokines by abdominal macrophages. This evidence concerns the gene IL1B and rheumatoid arthritis.