Chemotherapy agents affect HDL metabolism in varying ways: docetaxel increases HDL and decrease TG levels in the serum of mice bearing Ehrlich tumor (Alkhatib et al., 2017), but doxorubicin decreases HDL biogenesis by reducing the expression of ABCA1 and apoA-I, while cyclophosphamide and paclitaxel show no significant effect on HDL biogenesis (Sharma et al., 2016). The gene discussed is APOA1; the disease is Ehrlich tumor carcinoma.