GSDMD and Sepsis: In addition, activation of GSDMD mediates phosphatidylserine exposure, boosts the coagulation cascade, and promotes the process of disseminated intravascular coagulation (DIC), a complication mediating organ dysfunction or even death in sepsis (Levi & Ten Cate, 1999; Dhainaut et al., 2004; Zeerleder et al., 2005; Yang et al., 2019; Iba & Levy, 2020).