A series of studies have shown that deficiency of caspase-11 and GSDMD protects against lethal endotoxemia (Kayagaki et al., 2011; Kayagaki et al., 2013; Shi et al., 2014; Kayagaki et al., 2015; Shi et al., 2015) and prevents DIC in sepsis (Yang et al., 2019). The gene discussed is GSDMD; the disease is Sepsis.