HT successfully inhibited inflammatory angiogenesis in phorbol myristate acetate (PMA) stimulated endothelial cells through inhibition of proinflammatory enzyme cyclooxygenase (COX)-2 and matrix degrading enzymes matrix metalloproteinases (MMPs) which are proinflammatory mediators in cancer and atherosclerosis (Fortes et al., 2012; Scoditti et al., 2012). Here, PTGS2 is linked to cancer.