Protein tyrosine phosphatase 1B (PTP1B) is a non-trans membranous protein that acts as a major negative regulator of insulin signaling pathways, thereby mediating insulin resistance (Haj et al., 2003; Cho, 2013; Abdelsalam et al., 2019; Hussain et al., 2019). Here, PTPN1 is linked to Insulin resistance.