Blocking Kv1.3 and CRAC channels inhibits cytokines production and proliferation (Cahalan and Chandy, 2009; Feske et al., 2012; Hu et al., 2013; Although the function of Kv1.3 and CRAC channels in T cell function is relatively clear, their function in cancer remains unclear. The gene discussed is KCNA3; the disease is cancer.