AD is a neurodegenerative disease characterized by cholinergic deficits, neuronal loss, glial dysfunction (Echeverria et al., 2009), intracellular and extracellular accumulation of aggregated forms of Aβ, and the appearance of intraneuronal neurofibrillary tangles of hyperphosphorylated Tau in the brain (McGeer, 1986; Mann, 1989; Masdeu et al., 2005). This evidence concerns the gene MAPT and Alzheimer disease.