A further study investigated the therapeutic potential of the prenylflavonoid xanthohumol obtained from Humulus lupulus L for AD in neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APP), considered a cellular model of AD and HEK293/Tau cells, showing tau hyperphosphorylation. The gene discussed is MAPT; the disease is Alzheimer disease.