Compared with the MC group, the contents of IL-6, TNF-α, IFN-γ, IL-17A, and IL-10 in the LREE (0.5, 1, and 2 g/kg) groups were significantly decreased (P< 0.05), which indicated that LREE could significantly reduce the contents of cytokines in colon tissue and improve intestinal inflammation of mice with ulcerative colitis induced by DSS. The gene discussed is IL10; the disease is ulcerative colitis.