MAPT and Alzheimer disease: Additionally, we confirmed that pathological tau alterations in cortical and hippocampal areas were present in the brains of htau mice; observations that agree with previously published analyses of this mouse (Andorfer et al., 2003), resembling neuropathological features observed in late onset AD brains (Hyman et al., 2012; Montine et al., 2012; DeTure and Dickson, 2019; Figure 1C).