MAPT and Alzheimer disease: Furthermore, htau mice develop pathologies that effectively model spatiotemporal and histopathological features seen in AD, such as age-dependent hyperphosphorylation of tau in the hippocampus and frontal cortex, somatic redistribution of tau to dendritic compartments, tau aggregation into NFT-like structures, increased inflammation, decreased cortical thickness, and neuronal cell death (Andorfer et al., 2003).