SNCA and Parkinson disease: All PD-related mutations of SNCA, A30P, E46K, H50Q, G51D, and A53T are located in the amphiphilic region, suggesting the role of α-synuclein/lipid interactions in the pathogenesis of PD (Polymeropoulos et al., 1997; Kruger et al., 1998; Zarranz et al., 2004; Appel-Cresswell et al., 2013; Lesage et al., 2013; Proukakis et al., 2013).