PTEN and central nervous system cancer: Moreover, confocal microscopy and immunoprecipitation assays have shown that Cx43 binds to PTEN (González-Sánchez et al., 2016) and that the antiproliferative effect of Cx43, the major protein forming gap junctions in astrocytes, is reduced in glioma cells and astrocytes when Pten levels are reduced using NT-siRNA approaches (González-Sánchez et al., 2016).