NOD2 and myocarditis: In CVB3-induced myocarditis, once CVB3 is recognized by NOD2, the NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome will be activated to transform pro-Caspase-1 precursors into active Caspase-1 through three modes of intracellular potassium efflux and lysosomal membrane permeability leading to the release of cathepsin B and ROS (reactive oxygen species).