PALB2 consists of several protein domains including N-terminal coiled- coil domain-that interacts with BRCA1, C terminal WD40 domain-that interacts with BRCA2 and Chromatin Association Motif (ChAM)-that promotes chromatin association [3].Impairment of N-terminal coiled-coil domain-BRCA1interaction is associated with breast cancer risk [4]. The gene discussed is PALB2; the disease is breast cancer.