In a randomized controlled trial, Melatonin administration for 12 weeks in PCOS patients had beneficial effects on mental health parameters, insulin levels, homeostasis model of assessment-insulin resistance (HOMA-IR), the quantitative insulin sensitivity check index (QUICKI), total- and low-density lipoprotein cholesterol (LDL-C) levels [25]. The gene discussed is INS; the disease is Insulin resistance.